Tretinoin TAN Strong Cream (Tretinoin / Azelaic Acid / Niacinamide) 0.045/4/4%

Tretinoin TAN Strong Cream (Tretinoin / Azelaic Acid / Niacinamide) 0.045% / 4% / 4% is a compounded topical formulation designed to support acne treatment, skin rejuvenation, and hyperpigmentation correction through a multi-mechanism approach. Tretinoin 0.045% – A retinoid (vitamin A derivative) that increases cell turnover, promotes collagen production, and reduces fine lines, acne lesions, and uneven skin texture. It is widely used in dermatology for photoaging and acne management. Azelaic Acid 4% – A dicarboxylic acid with antimicrobial and anti-inflammatory properties, helping to reduce acne-causing bacteria, calm redness, and improve hyperpigmentation and melasma. Niacinamide 4% – A form of vitamin B3 that supports skin barrier function, reduces inflammation, regulates sebum production, and improves overall skin tone and texture. This combination works synergistically to address breakouts, discoloration, and signs of aging, making it suitable for patients seeking comprehensive skin improvement. The “TAN Strong” formulation reflects a higher-strength blend for more resistant skin concerns. Clinical use of tretinoin in acne and photoaging: https://pubmed.ncbi.nlm.nih.gov/15066137/ Azelaic acid in acne and hyperpigmentation: https://pubmed.ncbi.nlm.nih.gov/18561588/ Niacinamide and skin barrier/anti-inflammatory effects: https://pubmed.ncbi.nlm.nih.gov/17147561/