Naltrexone HCL Capsule 3mg

Naltrexone HCl 3 mg Capsule is a low-dose formulation of naltrexone, an opioid receptor antagonist traditionally used at higher doses for the treatment of opioid and alcohol dependence. At lower doses (commonly referred to as Low Dose Naltrexone, or LDN), it is used off-label in clinical practice for its potential immunomodulatory and anti-inflammatory effects. Naltrexone works by competitively binding to opioid receptors (primarily μ-opioid receptors), temporarily blocking endogenous and exogenous opioids. At low doses, this brief receptor blockade is thought to trigger a rebound increase in endorphin and enkephalin production, which may help regulate immune function and reduce inflammation. A 3 mg capsule is a common LDN dosing strength used in investigational and off-label protocols for conditions such as autoimmune disorders, chronic pain syndromes, and inflammatory conditions. While the exact mechanism in these settings is still being studied, research suggests that LDN may also modulate microglial activity in the central nervous system, contributing to reduced neuroinflammation. Clinical and mechanistic reviews describe naltrexone’s role as an opioid receptor antagonist and its emerging use in low-dose applications: https://www.ncbi.nlm.nih.gov/books/NBK534811/ Additional research discusses LDN’s potential effects on inflammation and immune modulation: https://pubmed.ncbi.nlm.nih.gov/29885638/