Long R3-IGF-1 600 mcg

Long R3 IGF-1 (Insulin-Like Growth Factor-1) 600 mcg is a synthetic analog of endogenous IGF-1 designed with an extended half-life and enhanced biological activity. It differs from native IGF-1 by the substitution of arginine at position 3 and the addition of a 13-amino-acid extension at the N-terminus, which reduces binding to IGF-binding proteins (IGFBPs). This modification increases its bioavailability and prolongs its activity in circulation. IGF-1 is a peptide hormone primarily produced in the liver in response to growth hormone (GH) stimulation and plays a central role in cell growth, proliferation, and tissue repair. Long R3 IGF-1 mimics these effects by binding to the IGF-1 receptor (IGF-1R), activating intracellular signaling pathways such as PI3K/Akt and MAPK, which are involved in protein synthesis, muscle growth, and cellular regeneration. A 600 mcg vial typically contains a lyophilized powder intended for reconstitution in controlled research settings. Due to its reduced affinity for IGF-binding proteins, Long R3 IGF-1 exhibits a significantly longer half-life compared to native IGF-1, allowing for more sustained receptor activation. Research has demonstrated that IGF-1 plays a critical role in growth, metabolism, and anabolic processes: https://www.ncbi.nlm.nih.gov/books/NBK507808/ Additionally, IGF-1 signaling is well established in regulating cell proliferation and survival pathways: https://pubmed.ncbi.nlm.nih.gov/10962022/