Bi-Amino Injection (Arginine HCl / Citrulline) 100/100 mg/mL 30 mL

Bi-Amino Injection (L-Arginine HCl / L-Citrulline) 100/100 mg/mL, 30 mL is a research amino acid solution combining two conditionally essential amino acids—L-arginine and L-citrulline—in equal concentrations. This injectable formulation is often discussed in the context of vasodilation, nitric oxide (NO) production, and cardiovascular support, though it is typically used in research settings and not approved by the FDA for specific medical indications. L-Arginine is a precursor for nitric oxide, a signaling molecule that relaxes blood vessels and supports blood flow and endothelial function. Clinical studies of supplemental arginine suggest potential benefits in conditions related to endothelial dysfunction and NO regulation, including hypertension and pulmonary hypertension, though optimal dosing and clinical utility continue to be researched. L-Citrulline is metabolized into arginine in the kidneys and may increase plasma arginine more effectively than arginine itself due to reduced first-pass metabolism. This can support sustained nitric oxide production and vascular responses. Together, arginine and citrulline are theorized to enhance nitric oxide availability, which could support vascular tone, exercise performance, and recovery. However, robust human clinical evidence for injectable combinations is limited, and most supportive data come from oral supplementation studies and mechanistic research. Links for more information: Product overview: https://www.estarpharma.com/product/bi-amino-injection/ Clinical review of arginine/citrulline supplementation: https://pubmed.ncbi.nlm.nih.gov/32140997/ Arginine/citrulline pharmacology review (full text): https://pmc.ncbi.nlm.nih.gov/articles/PMC7274894/